Use the indicated weapon to defeat the corresponding enemy:
Zombies (as Claire): Bowgun with Normal Arrows as much as possible, and if not, the Handgun.
Cerebuses (dogs): If you fight one on one, attack with one Handgun bullet, then Knife it to death. Otherwise, use the Handgun.
Bandersnatchers (enemies with long arms): Grenade Launcher with Explosive Rounds. Otherwise, Acid Rounds or Bowgun with Powder Arrows. If they live after one shot, use the Handgun or Bowgun with normal arrows, or if playing as Chris, use the Shotgun.
Tyrant 1 (on walkway): Grenade Launcher with Explosive Rounds. Otherwise the Acid Rounds or the Bowgun with Powder Arrows.
Tyrant 2 (on airplane): Grenade Launcher with all 3 B.O.W. Rounds followed by a few Bow Gun Powder Arrows to finish the job or the Grenade Launcher. Then, fire the catapult.
Moths: Run away; there is no need to kill them.
Spiders: Grenade Launcher with Explosive Rounds. Otherwise, Claire's Custom Handgun. If you do not have anything important to pick-up in the area, just run away.
Nosferatu (Boss with exposed heart): Sniper's Rifle through the heart. Otherwise, Bow Gun Powder Arrows, M150-P, Bow Gun with Normal Arrows, or Grenade Launcher with Grenade Rounds.
Digger (worm-like creature): Assault Rifle. Otherwise, M150-P, Claire's Custom Handgun, or anything else.
Zombies (as Chris): Claire's Custom Handgun. Otherwise, any Handgun or the Bow Gun.
Hunters (frog-like enemies with claws): Grenade Launcher with Explosive Rounds. Otherwise, Acid Rounds. If they live after one shot, use the Shotgun.
Tentacles: Any Handgun. As Claire, use Chris' handgun or Claire's Custom Handgun if available.
Giant Spider: Run away; there is no need to kill them.
Alexia 1 (Alexia using Blood to create fire): Shotgun. Otherwise, Grenade Launcher with any rounds or the Magnum.
Morphed Steve (Nosferatu-like Steve wielding a huge Ax): Run away.
Alexia 1 1/2 (Alexia going to 1-hit kill Claire): Shotgun or Magnum.
Alexia 2 (Alexia as a huge creature spewing out little creatures): Magnum. Otherwise, Grenade Launcher with Explosive Rounds, Rounds, or Shotgun.
Alexia 3 (Alexia flying around the screen): Get the Linear Launcher and use it.