Get two strikes on a batter. This is easiest done with a curveball. Then, throw a cutter high and away (outside the zone). The batter will swing and miss for strike three. This only works with right-handed pitchers against right-handed batters. If the batter does not swing, use a low and inside curveball to finish him off.
To get easy strikeouts and even a perfect game, get a pitcher with a slider and a curveball. If the batter hits from the same side as the pitcher throws, throw three sliders up and inside. Make sure it is over the edge of the zone slightly. If the batter hits from the opposite side as the pitcher, throw three curveballs up and inside (edge of the zone). Most of the time they will not swing, and you will strikeout almost every batter. Even if they do hit it, it will most likely be a popup.
Make the batter hit two or three foul balls, then throw either a changeup or slider. This will work about 90% of the time.
A good strikeout pitcher must have a curveball, and a four seam fastball (for example, Matt Morris). Start by throwing a curve in the batter's cold zone. Then, throw a fastball in the same or another cold zone. Finish him off with a curveball down and in.
Hint: Perfect game:
Use Barry Zito or create a player that has a good slider and curveball. Throw the slider two times to the opposite side that the pitcher throws. For example, Zito is left-handed, so throw it to the right side (inside of a left-handed batter). This will cause the batter to think it is either to the inside or to the outside. The pitch must be at the edge of the strike zone. After that, throw a curveball in the upper inside or outside corner. He should strike out, pop out, or ground out.
Glitch: Baseballs bounce on water:
When you hit homeruns at the Pittsburgh Pirates' PNC Park, use the "Replay" feature to follow the path of the ball closely. If the homeruns are deep enough to clear the stadium and land in the river that is just beyond the park, you will see that the balls do not fall and splash into the water. They bounce and roll on the water of the river, as if it were normal ground.